Olaniyi T Adedosu, Akinola N Adedosu, Gbadebo E Adeleke and Gbemisola B Balogun
Keywords: Anti- malarial, lipid peroxidation, hepatoprotective, nephroprotective, antioxidants.
Abstract: With the common practice in poor Africa endemic area to take local antimalaria herbs in combination with orthodox medicine and the increasing resistance to anti-malarial drugs, this study investigates the roles of methanol leaves extract of Vernonia amygdalina, in combination with artesunate. 24 male wistar rats weighing 190g were randomly grouped, administered therapeutic doses of artesunate and extract. Plasma total protein, urea, creatinine. Alanine. amino transferase (ALT), Alkaline phosphatase (ALP) and Gamma glutamyl transferase (GGT) were determined using international standardized methods. Percentage inhibition of lipid peroxidation, Malondialdehyde, (MDA), reduced glutathione (GSH) levels were determined spectrophotometrically. Results shows that extract conferred above 50% cell protection as it inhibited lipid peroxidation ,decreases MDA level significantly (P?0.05) and increases GSH level significantly (P?0.05) compared with controls, Artesunate alone and combined treatment of artesunate and extract. Plasma total protein concentrations were significantly (P?0.05) increased in all treatment groups . Artesunate alone significantly increased (P?0.05) plasma ALT, ALP and liver GGT activities while the combined treatments showed a modulatory effect as these activities were significantly decreased (P?0.05) nearly to control levels .Also, artesunate elicit significant (P?0.05) increases in plasma urea and creatinine concentrations which were attenuated to control levels in the combined treatment.Results are indicative of extract ability to inhibit lipid peroxidation, boost GSH formation, increases antioxidant status, shows hepatoprotective and nephroprotective effects.
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