Fatma Hashem, Hemaia Motawea, Manal Shabana, Maysa Elsayed Moharam, Mai Khalil and Taha Al-Alfy
Keywords: Ehretia wallichiana, desmutagenic activity, antimutagenic activity, rosmarinic acid and ethyl rosmarinate
Abstract: The ethyl acetate, ethanolic extract and total ethanol extract of Ehretia wallichiana Hook.f. & Thomson ex Gamble were tested for desmutagenic and antimutagenic activity. All of them have antimutagenic activity but lack desmutagenic activity. Ethyl acetate has highest activity as free radical scavenger (97.6%) in comparison with other extracts followed by total ethanol extract (88.7%), which may be attributed to flavonoids and other phenolics in the extracts. Betulinic acid, 9-hydroxy-10, 12, 15 octadecatrienoic acid methyl ester, Rosmarinic acid and ethyl rosmarinate were isolated from ethanolic extract. This is the first report of rosmarinic acid and ethyl rosmarinate isolated from Ehretia wallichiana. This is the first report of ethyl rosmarinate in genus Ehretia
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