CYTOSOLIC CALCIUM MEASUR EMENT FOR SI NGLE- CELL DRUG EFFICACY AND CARDIO TOXI CITY EVALUATIONS USING M I CROFLUIDIC BIOCHIPS Page No: 2663-2669

Xi u Ju n Li and Pa u l C H Li

Keywords: Cytosolic calcium , microflu idi c chip, cytot o xicity, drug e f ficacy, dr ug c ardi o toxicity, single-cell anal ysis , h e rb al ing r ed ien ts, licorice

Abstract: Intracell u lar ca lciu m ([Ca 2 ] i ) regu lates a d i v erse ran g e of cellu lar fu n ction s an d sign aling pathways. Th is rev i ew article aim s to highlight a pplications of m i crof luidi c single-cell a n alysis in drug discovery incl udi ng drug e ffi cacy test a n d drug side-e ffect test, base d on intr a cellular calcium measurem ent.



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