Prasad BalamuruganG and Arun Kumar K
Keywords: Induced effects, sodium fluoride, aluminum, cholinesterase, Oreochromis mossambicus.
Abstract: The combined action of sodium fluoride and aluminum chloride on Cholinesterase activity was studied by exposing fresh water fish Oreochromis mossambicus to varying concentration at different time intervals. In cerebellum, Cholinesterase activity decreased at 150ppm and 337.5ppm of aluminum chloride. In 225ppm of aluminum chloride no significant inhibition was found. In the brain tissue of medulla oblongata, Cholinesterase activity was significantly increased at (P<0.05) at 48 hrs and 96 hrs for 150ppm for aluminium chloride. The Cholinesterase activity significantly decreased (P<0.05) for 225ppm and 337.5ppm of aluminium chloride exposure the same was observed for all duration of exposures. Cholinesterase activity was significantly high at all duration of exposure. In the liver tissue the acetyl chloine activity decreased at all low concentration of exposure with respect to aluminium chloride. Whereas higher concentration (337.5ppm) significant (p<0.05) enzyme inhibition was decreased at 96hrs and 21 day of exposure. Sodium fluoride significantly (P<0.001) increased the enzyme activity at 24hrs and 96hrs of exposure alone. But the effect was counteracted when same animal was exposed to aluminium chloride for all duration of exposure periods.
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