Geeta Kaura , Ashish Suttee, Disha Arora and Anupum Sharma
Keywords: Caesalpinia bonduc, Eisenia foetida, anthelmintic, piperazine citrate.
Abstract: The in vitro anthelmintic activity of Caesalpinia bonduc leaves was evalauated. Four extracts viz. Petroleum ether, Dichloromethane (DCM), Ethyl acetate and Ethanol extracts of Caesalpinia Bonduc leaves were investigated for the anthelmintic activity against Earthworms (Eisenia foetida). Three concentrations (20, 40, 60mg/ml) of each extract were studied which included the determination of time of paralysis and time of death of earthworms. Piperazine citrate (10mg/ml) was used as standard drug and distilled water containing 2% Tween 80 was used as control. All the extracts exhibited dose dependent anthelmintic activity. The decreasing order of activity of extracts was ethyl acetate, ethanol, DCM and petroleum ether extracts. An Ethyl acetate extract of plant leaf exhibited in vitro anthelmintic activity in a concentration range of (20-60mg/ml). Conclusively, ethyl acetate extract of Caesalpinia bonduc leaves possesses vermicidal activity and found to be effective as an anthelmintic.
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