A A Osowole, R Kempe, R Schobert and S A Balogun
Keywords: Antibacterial and anticancer activities, cis-platin –sensitive and –resistant cell lines, Schiff base.
Abstract: Synthesis, spectroscopic characterisation and in-vitro antibacterial and anticancer studies were done on the neutral bidentate (NO) Schiff base, 3-(-1-(4-methyl-6-chloro)-2-pyrimidinyl imino)methyl-2-napthol and its Mn(II), Co(II), Ni(II), Pd(II), Cu(II) and Zn(II) complexes. These complexes assumed a 4-coordinate tetrahedral /square-planar geometry as corroborated by room temperature magnetic data, IR and electronic spectral measurements. The conductance data confirmed their covalent nature while mass spectra and TGA data affirmed the proposed structure. The ligand was not sensitive to HL 60 (leukaemia) but resistant to 518A2 (melanoma) carcinomas. The Pd(II) complex had the best cytotoxic activities against HL 60 (Leukemia) and Melanoma (518A2) carcinomas with IC50 of 11.89 and 9.11 ?m at 48 and 72 h respectively, which was a third as, and four times more sensitive than CDDP (Cis-platin). The complexes generally exhibited good antibacterial activities against five Gram negative (E. cloacae, S. arizona, Serratia sp, E. Coli) and three Gram positive (C. violaceum, S. aureus, Bacillus sp) bacteria with inhibitory zones range of 7-19 mm. Similar to gentamycin, the Cu(II) and Zn(II) complexes had broad-spectrum activity against the bacteria used, although much lower.
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