Tanveer Ahmad Khan, Kok Khiang Peh, and Khurshid Anwar
Keywords: Chitosan, Zeta potential, Peel adhesion, tensile strength
Abstract: Chitosan is a biopolymer, made up of glucosamine and N-acetyl-D-glucosamine units which are constituents of mammalian tissues. Chitosan (1.4%w/v) in 1% acetic acid (Chit-S1-AA) and in 2% lactic acid (Chit-S1-LA) solutions were prepared and their zeta potential (ZP) determined before being cast to prepare films for wound dressing. The peel adhesion test and swelling behaviour of these films were studied. The ZP values of Chit-S1-LA and Chit-S1-AA solutions were differed significantly (p < 0.05). The peel force (p=0.016) and work of peel (p=0.004) results were significantly different between Chit-S1-AA and Chit-S1-LA. The degree of swelling for Chit-S1-LA film in distilled water was higher than in phosphate buffer solution. Conversely, Chit-S1-AA films swelled to a comparatively greater extent in the phosphate buffer solution than in distilled water. There was a statistically significant difference in the rate of moisture permeability between Chit-S1-AA and Chit-S1-LA (p<0.001). The tensile strength of both Chit-S1-AA and Chit-S1-LA films decreased significantly with an increase in the relative humidity (p < 0.001) or the exposure duration (p < 0.001). In contrast, the elongation of both the films increased significantly with an increase in the relative humidity (p<0.05) or the exposure duration (p<0.001).
[View Complete Article]